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The antibody against PTF1A was raised in rabbit using the Recombinant Human Pancreas transcription factor 1 subunit alpha protein (224-325AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against PTF1A was raised in rabbit using the Recombinant Human Pancreas transcription factor 1 subunit alpha protein (224-325AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PTF1A Antibody at dilution of 1:1002
| Cat.No | ADC-10825A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PTF1A |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Pancreas transcription factor 1 subunit alpha protein (224-325AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7RTS3 |
Uniprot Id
Q7RTS3
Target Species
Human
Target Name
PTF1A
Target Full Name
Pancreas transcription factor 1 subunit alpha
Target Function
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
Target Involvement
Pancreatic and cerebellar agenesis (PACA); Pancreatic agenesis 2 (PAGEN2)
Target Subcellular Location
Nucleus. Cytoplasm.
Target Tissue Specificity
Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers.
Target Synonyms
bHLH transcription factor p48; bHLHa29; Class A basic helix-loop-helix protein 29; Class II bHLH protein PTF1A; Exocrine pancreas specific transcription factor p48; p48 DNA binding subunit of transcription factor PTF1; p48 DNA-binding subunit of transcription factor PTF1; PACA; PAGEN2; Pancreas specific transcription factor 1a; Pancreas transcription factor 1 subunit alpha; Pancreas-specific transcription factor 1a; PTF 1A; PTF1 p48; PTF1-p48; Ptf1a; PTF1A_HUMAN; PTF1P48
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