Rabbit anti-Human PTP4A1 Polyclonal Antibody

Uniprot Id

Q93096

Target Species

Human

Target Name

PTP4A1

Target Full Name

Protein tyrosine phosphatase type IVA 1

Target Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.

Target Subcellular Location

Cell membrane; Lipid-anchor. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Nucleus.

Target Protein Families

Protein-tyrosine phosphatase family

Target Tissue Specificity

Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.

Target Synonyms

HH 72; HH72; Hypothetical protein DKFZp779M0721 ; Phosphatase of regenerating liver 1; PRL 1; PRL-1; PRL1; Protein tyrosine phosphatase PTPCAAX1; Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase type IVA member 1; Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; Protein-tyrosine phosphatase; type 4A; 1; PTP(CAAXI); Ptp4a1; PTPCAAX1; TP4A1_HUMAN

Target Background

This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X.