Rabbit anti-Human PTPN23 Polyclonal Antibody

Uniprot Id

Q9H3S7

Target Species

Human

Target Name

PTPN23

Target Full Name

Tyrosine-protein phosphatase non-receptor type 23

Target Function

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.

Target Subcellular Location

Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.

Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class subfamily

Target Synonyms

DKFZP564F0923; EC 3.1.3.48; HD PTP; HD-PTP; His domain containing protein tyrosine phosphatase; His domain protein tyrosine phosphatase; His domain-containing protein tyrosine phosphatase; KIAA1471; Protein tyrosine phosphatase non receptor type 23; Protein tyrosine phosphatase TD 14; Protein tyrosine phosphatase TD14; PTN23_HUMAN; PTP TD14; PTP-TD14; PTPN 23; PTPN23; Tyrosine protein phosphatase non receptor type 23; Tyrosine-protein phosphatase non-receptor type 23

Target Background

This gene encodes a member of the non-receptor type protein-tyrosine phosphatase family. The encoded protein may be involved in the regulation of small nuclear ribonucleo protein assembly and pre-mRNA splicing by modifying the survival motor neuron (SMN) complex. The encoded protein additionally plays a role in ciliogenesis and is part of endosomal sorting complex required for transport (ESCRT) pathways. This gene may serve a tumor suppressor function.