Rabbit anti-Human PTPRK Polyclonal Antibody

Uniprot Id

Q15262

Target Species

Human

Target Name

PTPRK

Target Full Name

Receptor-type tyrosine-protein phosphatase kappa

Target Function

Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.

Target Subcellular Location

Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Protein-tyrosine phosphatase family, Receptor class 2B subfamily

Target Tissue Specificity

High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.

Target Synonyms

dJ480J14.2.1; DKFZp686C2268; DKFZp779N1045; OTTHUMP00000017180; OTTHUMP00000017181; OTTHUMP00000017182; OTTHUMP00000017187; OTTHUMP00000040306; Protein tyrosine phosphatase kappa; Protein tyrosine phosphatase kappa precursor; Protein tyrosine phosphatase receptor type K; Protein tyrosine phosphatase receptor type kappa; Protein-tyrosine phosphatase kappa; PTPK; PTPkappa; Ptprk; PTPRK_HUMAN; R PTP kappa; R-PTP-kappa; Receptor type tyrosine protein phosphatase kappa; Receptor-type tyrosine-protein phosphatase kappa

Target Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.