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The antibody against PVRIG was raised in rabbit using the Recombinant Human Transmembrane protein PVRIG protein (193-326AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against PVRIG was raised in rabbit using the Recombinant Human Transmembrane protein PVRIG protein (193-326AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
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Western BlotPositive WB detected in: Hela whole cell lysateAll lanes: PVRIG antibody at 1:1000SecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 35 kDaObserved band size: 35 kDa
Immunofluorescent analysis of A549 cells using PVRIG Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
Western BlotPositive WB detected in: JK whole cell lysateAll lanes: PVRIG antibody at 1:1000SecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 35 kDaObserved band size: 35 kDa3
| Cat.No | ADC-19914A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PVRIG |
| Target Synonyms | PVRIG; C7orf15; Transmembrane protein PVRIG; CD112 receptor; CD112R; Poliovirus receptor-related immunoglobulin domain-containing protein | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Transmembrane protein PVRIG protein (193-326AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6DKI7 |
Uniprot Id
Q6DKI7
Target Species
Human
Target Name
PVRIG
Target Full Name
Transmembrane protein PVRIG
Target Function
Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Tissue Specificity
Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-
Target Synonyms
PVRIG; C7orf15; Transmembrane protein PVRIG; CD112 receptor; CD112R; Poliovirus receptor-related immunoglobulin domain-containing protein
Target Background
Enables phosphatase binding activity and signaling receptor activity. Involved in negative regulation of T cell receptor signaling pathway. Located in plasma membrane.
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