Rabbit anti-Human Rad21 Monoclonal Antibody

The antibody against Rad21 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 532-631 of human Rad21 (O60216) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ChIP, ChIP-seq, ELISA.

ADA-14274A

Number

Cat.No	ADA-14274A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	RAD21
Target Synonyms	MGS; HR21; MCD1; NXP1; SCC1; CDLS4; hHR21; HRAD21; Rad21	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	C6, HeLa, NIH/3T3, A549	Application	ELISA, WB, ChIP, ChIP-seq, IP

Cat.No

ADA-14274A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

RAD21

Target Synonyms

MGS; HR21; MCD1; NXP1; SCC1; CDLS4; hHR21; HRAD21; Rad21

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

C6, HeLa, NIH/3T3, A549

Application

ELISA, WB, ChIP, ChIP-seq, IP

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 532-631 of human Rad21 (O60216).	Target Species	Human
Immunogen Sequence	EKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII	Uniprot ID	O60216

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 532-631 of human Rad21 (O60216).

Target Species

Human

Immunogen Sequence

EKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII

Uniprot ID

O60216

Background Information

Uniprot Id

O60216
Target Species

Human
Target Name

RAD21
Target Full Name

Double-strand-break repair protein rad21 homolog
Target Function

As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis. In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome. May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter. May play a role in embryonic gut development, possibly through the regulation of enteric neuron development.; May promote apoptosis.
Target Involvement

Cornelia de Lange syndrome 4 (CDLS4)
Target Subcellular Location

[Double-strand-break repair protein rad21 homolog]: Nucleus. Nucleus matrix. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole.; [64-kDa C-terminal product]: Cytoplasm, cytosol. Nucleus.
Target Protein Families

Rad21 family
Target Tissue Specificity

Expressed in the gut (at protein level).
Target Synonyms

CDLS4; Double-strand-break repair protein rad21 homolog; hHR21; HR21; HRAD21; KIAA0078; MCD1; Nuclear matrix protein 1; NXP-1; NXP1; Protein involved in DNA double-strand break repair; RAD21; RAD21 homolog (S. pombe); RAD21 homolog; RAD21_HUMAN; Scc1; SCC1 homolog
Target Background

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.

Rabbit anti-Human Rad21 Monoclonal Antibody

Specifications

Immunogen Information

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