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The antibody against RAPGEF1 was raised in rabbit using the Peptide sequence from Human Rap guanine nucleotide exchange factor 1 protein (22-40AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against RAPGEF1 was raised in rabbit using the Peptide sequence from Human Rap guanine nucleotide exchange factor 1 protein (22-40AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
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Western Blot_x000D_ | Positive WB detected in: HL60 whole cell lysate, SH-SY5Y whole cell lysate_x000D_ | All lanes: RAPGEF1 antibody at 1:2000_x000D_ | Secondary_x000D_ | Goat polyclonal to rabbit IgG at 1/50000 dilution_x000D_ | Predicted band size: 121, 117, 123 kDa_x000D_ | Observed band size: 121 kDa
| Cat.No | ADC-01218A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RAPGEF1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Peptide sequence from Human Rap guanine nucleotide exchange factor 1 protein (22-40AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13905 |
Uniprot Id
Q13905
Target Species
Human
Target Name
RAPGEF1
Target Full Name
Rap guanine nucleotide exchange factor 1
Target Function
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.
Target Subcellular Location
Early endosome.
Target Tissue Specificity
Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.
Target Synonyms
C3G; C3G protein; CRK SH3 binding GNRP; CRK SH3-binding GNRP; DKFZp781P1719; GRF 2; GRF2; Guanine nucleotide releasing factor 2 (specific for crk proto oncogene); Guanine nucleotide releasing factor 2; Guanine nucleotide-releasing factor 2; OTTHUMP00000064558; Protein C3G; Rap guanine nucleotide exchange factor (GEF) 1; Rap guanine nucleotide exchange factor 1; RAPGEF 1; RAPGEF1; RPGF1_HUMAN
Target Background
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
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