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The antibody against RASSF6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human RASSF6 (NP_001257320.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against RASSF6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human RASSF6 (NP_001257320.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03856A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RASSF6 |
| Target Synonyms | RASSF6 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse intestine, Rat kidney | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human RASSF6 (NP_001257320.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6ZTQ3 | Immunogen Sequence |
Uniprot Id
Q6ZTQ3
Target Species
Human
Target Name
RASSF6
Target Full Name
Ras association domain-containing protein 6
Target Function
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B.
Target Tissue Specificity
Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the n
Target Research Area
others
Target Synonyms
RASSF6; Ras association domain-containing protein 6
Target Background
This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms.
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