Rabbit anti-Human RBM5 Polyclonal Antibody

Uniprot Id

P52756

Target Species

Human

Target Name

RBM5

Target Full Name

RNA-binding protein 5

Target Function

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

Target Subcellular Location

Nucleus.

Target Protein Families

RBM5/RBM10 family

Target Tissue Specificity

Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.

Target Synonyms

FLJ39876; G15; H37; LUCA 15; LUCA15; Protein G15; Putative tumor suppressor LUCA15; RBM 5; Rbm5; RBM5_HUMAN; Renal carcinoma antigen NY REN 9; Renal carcinoma antigen NY-REN-9; RMB 5; RMB5; RNA binding motif protein 5; RNA binding protein 5; RNA-binding motif protein 5; RNA-binding protein 5; Tumor suppressor LUCA15

Target Background

This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer.