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The antibody against RC3H2 was raised in rabbit using the Recombinant Human Roquin-2 protein (251-506AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against RC3H2 was raised in rabbit using the Recombinant Human Roquin-2 protein (251-506AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-17937A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RC3H2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Roquin-2 protein (251-506AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HBD1 |
Uniprot Id
Q9HBD1
Target Species
Human
Target Name
RC3H2
Target Full Name
Roquin-2
Target Function
Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation. miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression. Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains. Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains. Involved in the ubiquitination of MAP3K5. Able to interact with double-stranded RNA (dsRNA).
Target Subcellular Location
Cytoplasm, P-body.
Target Tissue Specificity
Expressed in spleen, testis, ovary and small intestine.
Target Synonyms
2900024N03Rik; 9430019J22Rik; D930043C02Rik; FLJ20301; FLJ20713; Membrane associated DNA binding protein; Membrane associated nucleic acid binding protein; Membrane-associated nucleic acid-binding protein; MGC52176; MNAB; OTTHUMP00000022076; OTTHUMP00000022077; OTTMUSP00000013545; OTTMUSP00000013546; Rc3h2; RC3H2_HUMAN; Ring finger and CCCH type domains 2; RING finger and CCCH type zinc finger domain containing protein 2; Ring finger and CCCH-type zinc finger domain-containing protein 2; ring finger and CCCH-type zinc finger domains 2; RING finger protein 164; RNF164; roquin-2; RP23-321B3.1
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