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The antibody against RDH12 was raised in rabbit using the Recombinant Human Retinol dehydrogenase 12 protein (182-316AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against RDH12 was raised in rabbit using the Recombinant Human Retinol dehydrogenase 12 protein (182-316AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using RDH12 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using RDH12 Antibody at dilution of 1:1002
| Cat.No | ADC-16825A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RDH12 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Retinol dehydrogenase 12 protein (182-316AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96NR8 |
Uniprot Id
Q96NR8
Target Species
Human
Target Name
RDH12
Target Full Name
Retinol dehydrogenase 12
Target Function
Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids.
Target Involvement
Leber congenital amaurosis 13 (LCA13); Retinitis pigmentosa 53 (RP53)
Target Subcellular Location
Endoplasmic reticulum membrane.
Target Protein Families
Short-chain dehydrogenases/reductases (SDR) family
Target Tissue Specificity
Widely expressed, mostly in retina, kidney, brain, skeletal muscle, pancreas and stomach.
Target Research Area
Metabolism
Target Synonyms
All trans and 9 cis retinol dehydrogenase; All-trans and 9-cis retinol dehydrogenase; LCA 3; LCA13; LCA3; RDH 12; RDH12; RDH12_HUMAN; Retinol dehydrogenase 12 (all trans/9 cis/11 cis); Retinol dehydrogenase 12 all trans and 9 cis; Retinol dehydrogenase 12; RP53; SDR7C2; Short chain dehydrogenase/reductase family 7C member 2
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