Rabbit anti-Human RHOU Polyclonal Antibody

The antibody against RHOU was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 40-100 of human RHOU (NP_067028.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-02128A

Number

Cat.No	ADA-02128A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	RHOU
Target Synonyms	ARHU; G28K; WRCH1; hG28K; CDC42L1; RHOU	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	U-87MG	Application	ELISA, WB

Cat.No

ADA-02128A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

RHOU

Target Synonyms

ARHU; G28K; WRCH1; hG28K; CDC42L1; RHOU

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

U-87MG

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 40-100 of human RHOU (NP_067028.1).	Target Species	Human
Immunogen Sequence	GRAGGAEGRGVKCVLVGDGAVGKTSLVVSYTTNGYPTEYIPTAFDNFSAVVSVDGRPVRLQ	Uniprot ID	Q7L0Q8

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 40-100 of human RHOU (NP_067028.1).

Target Species

Human

Immunogen Sequence

GRAGGAEGRGVKCVLVGDGAVGKTSLVVSYTTNGYPTEYIPTAFDNFSAVVSVDGRPVRLQ

Uniprot ID

Q7L0Q8

Background Information

Uniprot Id

Q7L0Q8
Target Species

Human
Target Name

RHOU
Target Full Name

Rho-related GTP-binding protein RhoU
Target Function

Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Target Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome.
Target Protein Families

Small GTPase superfamily, Rho family
Target Tissue Specificity

Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.
Target Synonyms

ARHU; CDC42 L1; CDC42 like GTPase; CDC42-like GTPase 1; CDC42L1; G28K; GTP binding protein like 1; GTP binding protein SB128; GTP-binding protein-like 1; hG28K; mG28K; Ras homolog gene family member U; Ras homolog gene family member U isoform CRA a; Ras like gene family member U; Rho GTPase like protein ARHU; Rho GTPase-like protein ARHU; Rho related GTP binding protein RhoU; Rho-related GTP-binding protein RhoU; Rhou; RHOU_HUMAN; Ryu GTPase; Wnt-1 responsive Cdc42 homolog 1; Wnt1 responsive Cdc42 homolog; WRCH 1; WRCH-1
Target Background

This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.

Rabbit anti-Human RHOU Polyclonal Antibody

Specifications

Immunogen Information

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