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The antibody against RIMS2 was raised in rabbit using the Recombinant Human Regulating synaptic membrane exocytosis protein 2 protein (667-943AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against RIMS2 was raised in rabbit using the Recombinant Human Regulating synaptic membrane exocytosis protein 2 protein (667-943AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
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Immunofluorescent analysis of PC-3 cells using RIMS2 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-10004A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RIMS2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Regulating synaptic membrane exocytosis protein 2 protein (667-943AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UQ26 |
Uniprot Id
Q9UQ26
Target Species
Human
Target Name
RIMS2
Target Full Name
Regulating synaptic membrane exocytosis protein 2
Target Function
Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes.
Target Subcellular Location
Cell membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein.
Target Tissue Specificity
Widely expressed. Expressed in melanocytes. In fetal tissues, predominantly expressed in the brain. In the retina, expressed in the outer plexiform layer (at protein level). In the cerebellum, expressed in Purkinje cells (at protein level). In the pancrea
Target Synonyms
KIAA0751; Non small cell lung cancer RimL3a protein; Non small cell lung cancer RimL3c protein; OBOE; Protein regulating synaptic membrane exocytosis 2; Rab-3-interacting molecule 2; Rab-3-interacting protein 3; Rab3 interacting molecule 2; RAB3IP3; Regulating synaptic membrane exocytosis 2; Regulating synaptic membrane exocytosis protein 2; RIM 2; Rims2 (gene name); Rims2; RIMS2_HUMAN
Target Background
The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis.
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