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The antibody against RIOK2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 253-552 of human RIOK2 (NP_060813.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against RIOK2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 253-552 of human RIOK2 (NP_060813.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09262A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RIOK2 |
| Target Synonyms | RIO2; RIOK2 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T, HepG2, Jurkat | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 253-552 of human RIOK2 (NP_060813.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BVS4 | Immunogen Sequence |
Uniprot Id
Q9BVS4
Target Species
Human
Target Name
RIOK2
Target Full Name
Serine/threonine-protein kinase RIO2
Target Function
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Protein kinase superfamily, RIO-type Ser/Thr kinase family
Target Synonyms
FLJ11159; OTTHUMP00000158911; OTTHUMP00000222868; RIO kinase 2 (yeast) ; RIO kinase 2; RIO2; RIOK2; RIOK2_HUMAN; Serine/threonine protein kinase RIO2; Serine/threonine-protein kinase rio2
Target Background
Predicted to enable protein kinase activity. Involved in several processes, including positive regulation of rRNA processing; positive regulation of ribosomal small subunit export from nucleus; and regulation of mitotic metaphase/anaphase transition. Located in cytoplasm. Part of preribosome, small subunit precursor.
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