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Rabbit anti-Human RNASE3 Polyclonal Antibody

The antibody against RNASE3 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 100-160 of human RNASE3 (NP_002926.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-05607A

The antibody against RNASE3 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 100-160 of human RNASE3 (NP_002926.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-05607A ClonalityPolyclonal
Host SpeciesRabbitTarget NameRNASE3
Target SynonymsECP; RAF1; RNS3; RNASE3FormLiquid
Species ReactivityHuman, RatIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.01% thimerosal, pH7.3.Purification MethodAffinity purification
Positive SamplesK-562, Rat liver, Rat lungApplicationELISA, WB

Immunogen Information


Immunogen DescriptionA synthetic peptide corresponding to a sequence within amino acids 100-160 of human RNASE3 (NP_002926.2).Target SpeciesHuman
Immunogen SequenceRSRFRVPLLHCDLINPGAQNISNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTIUniprot IDP12724
Background Information
  • Uniprot Id

    P12724

  • Target Species

    Human

  • Target Name

    RNASE3

  • Target Full Name

    Eosinophil cationic protein

  • Target Function

    Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.

  • Target Subcellular Location

    Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.

  • Target Protein Families

    Pancreatic ribonuclease family

  • Target Synonyms

    ECP; RAF1; RNS3; RNASE3

  • Target Background

    The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria

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