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The antibody against RNASET2 was raised in rabbit using the Fusion protein of Human RNASET2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against RNASET2 was raised in rabbit using the Fusion protein of Human RNASET2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-29393A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RNASET2 |
| Target Synonyms | bA514O12.3 antibody; Ribonuclease 6 antibody; Ribonuclease T2 antibody; RNASE6PL antibody; Rnaset2 antibody; RNT2_HUMAN antibody; RP11 514O12.3 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Fusion protein of Human RNASET2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O00584 |
Uniprot Id
O00584
Target Species
Human
Target Name
RNASET2
Target Full Name
Ribonuclease T2
Target Function
Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs.
Target Involvement
Leukoencephalopathy, cystic, without megalencephaly (LCWM)
Target Subcellular Location
Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Mitochondrion intermembrane space.
Target Protein Families
RNase T2 family
Target Tissue Specificity
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
Target Research Area
Cancer
Target Synonyms
bA514O12.3; Ribonuclease 6; Ribonuclease T2; RNASE6PL; Rnaset2; RNT2_HUMAN; RP11 514O12.3
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