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The antibody against RNF212 was raised in rabbit using the Recombinant Human Probable E3 SUMO-protein ligase RNF212 protein (1-297AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against RNF212 was raised in rabbit using the Recombinant Human Probable E3 SUMO-protein ligase RNF212 protein (1-297AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human adrenal gland tissue using RNF212 Antibody at dilution of 1:100
| Cat.No | ADC-40333A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RNF212 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Probable E3 SUMO-protein ligase RNF212 protein (1-297AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q495C1 |
Uniprot Id
Q495C1
Target Species
Human
Target Name
RNF212
Target Full Name
Probable E3 SUMO-protein ligase RNF212
Target Function
SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination.
Target Subcellular Location
Nucleus. Chromosome.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
FLJ38841; Hypothetical protein LOC285498; LOC285498; OTTHUMP00000147525; Probable E3 SUMO-protein ligase RNF212; RING finger protein 212; RN212_HUMAN; RNF 212; RNF212; ZHP3 ; ZHP3; C. elegans; homolog of; ZIP3-related protein
Target Background
This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.
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