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The antibody against RNF31 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase RNF31 protein (421-700AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against RNF31 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase RNF31 protein (421-700AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human kidney tissue using RNF31 Antibody at dilution of 1:100
Immunofluorescent analysis of PC-3 cells using RNF31 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-23795A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RNF31 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human E3 ubiquitin-protein ligase RNF31 protein (421-700AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96EP0 |
Uniprot Id
Q96EP0
Target Species
Human
Target Name
RNF31
Target Full Name
E3 ubiquitin-protein ligase RNF31
Target Function
E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation. Binds polyubiquitin of different linkage types.
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Expressed in both normal and transformed breast epithelial cell lines.
Target Synonyms
E3 ubiquitin protein ligase RNF31; FLJ10111; FLJ23501; HOIL 1L interacting protein; HOIL-1-interacting protein; HOIL1L interacting protein; HOIP; RING finger protein 31; RNF31; RNF31_HUMAN; ZIBRA; Zinc in between ring finger ubiquitin associated domain; Zinc in-between-RING-finger ubiquitin-associated domain protein
Target Background
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The encoded protein is the E3 ubiquitin-protein ligase component of the linear ubiquitin chain assembly complex. Two transcript variants encoding different isoforms have been found for this gene.
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