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The antibody against RNF43 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase RNF43 protein (566-697AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against RNF43 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase RNF43 protein (566-697AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-05892A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RNF43 |
| Target Synonyms | RNF43 antibody; E3 ubiquitin-protein ligase RNF43 antibody; EC 2.3.2.27 antibody; RING finger protein 43 antibody; RING-type E3 ubiquitin transferase RNF43 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | HRP conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human E3 ubiquitin-protein ligase RNF43 protein (566-697AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q68DV7 |
Uniprot Id
Q68DV7
Target Species
Human
Target Name
RNF43
Target Full Name
E3 ubiquitin-protein ligase RNF43
Target Function
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification.
Target Involvement
Sessile serrated polyposis cancer syndrome (SSPCS)
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope.
Target Protein Families
ZNRF3 family
Target Tissue Specificity
Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.
Target Research Area
Cancer
Target Synonyms
RNF43; E3 ubiquitin-protein ligase RNF43; EC 2.3.2.27; RING finger protein 43; RING-type E3 ubiquitin transferase RNF43
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