Rabbit anti-Human RNH1 Polyclonal Antibody

Uniprot Id

P13489

Target Species

Human

Target Name

RNH1

Target Full Name

Ribonuclease inhibitor

Target Function

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

Target Subcellular Location

Cytoplasm.

Target Research Area

Cardiovascular

Target Synonyms

AW546468; C80305; MGC18200; MGC4569; MGC54054; OTTHUMP00000147628; OTTHUMP00000229864; OTTHUMP00000229865; OTTHUMP00000229866; OTTHUMP00000229870; OTTHUMP00000229871; OTTHUMP00000229872; Placental ribonuclease inhibitor; Placental RNase inhibitor; PRI; RAI; RI; Ribonuclease inhibitor; Ribonuclease/angiogenin inhibitor 1; Ribonuclease/angiogenin inhibitor; RINI_HUMAN; RNase inhibitor; RNH 1; RNH; RNH1; Rnh1 ribonuclease/angiogenin inhibitor 1

Target Background

Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50, 000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.