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Rabbit anti-Human ROBO2 Polyclonal Antibody

The antibody against ROBO2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 450-660 of human ROBO2 (NP_001122401.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01233A

The antibody against ROBO2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 450-660 of human ROBO2 (NP_001122401.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-01233A ClonalityPolyclonal
Host SpeciesRabbitTarget NameROBO2
Target SynonymsSAX3; ROBO2FormLiquid
Species ReactivityHuman, Mouse, RatIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.02% sodium azide, pH7.3.Purification MethodAffinity purification
Positive SamplesRat brain, A-549, Mouse brain, Mouse lung, SH-SY5Y, SKOV3ApplicationELISA, WB

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 450-660 of human ROBO2 (NP_001122401.1).Target SpeciesHuman
Uniprot IDQ9HCK4Immunogen Sequence
Background Information
  • Uniprot Id

    Q9HCK4

  • Target Species

    Human

  • Target Name

    ROBO2

  • Target Full Name

    Roundabout homolog 2

  • Target Function

    Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.

  • Target Involvement

    Vesicoureteral reflux 2 (VUR2)

  • Target Subcellular Location

    Membrane; Single-pass type I membrane protein.

  • Target Protein Families

    Immunoglobulin superfamily, ROBO family

  • Target Synonyms

    lea; Robo 2; Robo2; ROBO2_HUMAN; Roundabout 2; Roundabout homolog 2; roundabout, axon guidance receptor, homolog 2 (Drosophila); Roundabout2; SAX 3; SAX3

  • Target Background

    The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants.

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