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Rabbit anti-Human RPGRIP1 Polyclonal Antibody

The antibody against RPGRIP1 was raised in rabbit using the Human RPGRIP1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.

ADC-52026A

The antibody against RPGRIP1 was raised in rabbit using the Human RPGRIP1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.

$600.00

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Specifications


Cat.No ADC-52026A ClonalityPolyclonal
Host SpeciesRabbitTarget NameRPGRIP1
Target SynonymsRPGRIP1 antibody; X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 antibody; RPGR-interacting protein 1 antibodyFormLiquid
Species ReactivityHumanIsotypeIgG
Storage Buffer50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium AzidePurification MethodAntigen affinity purified
ConjugateNon-conjugatedApplicationELISA, WB
StorageUpon receipt

Immunogen Information


Immunogen DescriptionHuman RPGRIP1Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDQ96KN7
Background Information
  • Uniprot Id

    Q96KN7

  • Target Species

    Human

  • Target Name

    RPGRIP1

  • Target Full Name

    X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

  • Target Function

    May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells.

  • Target Involvement

    Leber congenital amaurosis 6 (LCA6); Cone-rod dystrophy 13 (CORD13)

  • Target Subcellular Location

    Cell projection, cilium.

  • Target Protein Families

    RPGRIP1 family

  • Target Tissue Specificity

    Strong expression in retina, with weaker expression in testis. Expressed in other neurons such as amacrine cells. Colocalizes with RGPR in the outer segment of rod photoreceptors and cone outer segments.

  • Target Synonyms

    RPGRIP1; X-linked retinitis pigmentosa GTPase regulator-interacting protein 1; RPGR-interacting protein 1

  • Target Background

    This gene encodes a photoreceptor protein that interacts with retinitis pigmentosa GTPase regulator protein and is a key component of cone and rod photoreceptor cells. Mutations in this gene lead to autosomal recessive congenital blindness.

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