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The antibody against RPN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human RPN1 (NP_002941.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against RPN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human RPN1 (NP_002941.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-10333A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RPN1 |
| Target Synonyms | OST1; RBPH1; RPN1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | BxPC-3, HepG2, HL-60, MCF7, Mouse liver, Rat liver, SKOV3 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human RPN1 (NP_002941.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P04843 | Immunogen Sequence |
Uniprot Id
P04843
Target Species
Human
Target Name
RPN1
Target Full Name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Target Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Target Subcellular Location
Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Target Protein Families
OST1 family
Target Tissue Specificity
Expressed in all tissues tested.
Target Research Area
Others
Target Synonyms
D6Wsu137e; Dolichyl diphosphooligosaccharide protein glycosyltransferase 67 kDa subunit; Dolichyl diphosphooligosaccharide protein glycosyltransferase 67 kDa subunit precursor; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; EC 2.4.1.119; Oligosaccharyltransferase 1 homolog; oligosaccharyltransferase complex subunit (non-catalytic); OST1; RBPH1; Ribophorin I; Ribophorin-1; RPN-I; Rpn1; RPN1_HUMAN
Target Background
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome.
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