Rabbit anti-Human RPS27 Polyclonal Antibody

Uniprot Id

P42677

Target Species

Human

Target Name

RPS27

Target Full Name

Small ribosomal subunit protein eS27

Target Function

Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs.

Target Involvement

Diamond-Blackfan anemia 17 (DBA17)

Target Protein Families

Eukaryotic ribosomal protein eS27 family

Target Tissue Specificity

Expressed in a wide variety of actively proliferating cells and tumor tissues.

Target Research Area

others

Target Synonyms

2610206D02Rik; 3200001M24Rik; 40S ribosomal protein S27; C530005D02Rik; Metallopan stimulin 1; Metallopan-stimulin 1; Metallopanstimulin 1; Metallopanstimulin1; MPS 1; MPS-1; MPS1; pmn; Ribosomal protein S27; Ribosomal protein S27 metallopanstimulin 1; rps27; RS27_HUMAN; S27; snoRNA MBI 112

Target Background

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.