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The antibody against RPUSD4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-377 of human RPUSD4 (NP_116184.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against RPUSD4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-377 of human RPUSD4 (NP_116184.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04982A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RPUSD4 |
| Target Synonyms | RPUSD4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, HT-29, Mouse spleen, Rat spleen, Rat testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-377 of human RPUSD4 (NP_116184.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96CM3 | Immunogen Sequence |
Uniprot Id
Q96CM3
Target Species
Human
Target Name
RPUSD4
Target Full Name
Pseudouridylate synthase RPUSD4, mitochondrial
Target Function
Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. Acts on position 39 in mitochondrial tRNA(Phe). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation.
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Pseudouridine synthase RluA family
Target Synonyms
RNA pseudouridylate synthase domain-containing protein 4; rpusd4; RUSD4_HUMAN
Target Background
Enables mitochondrial ribosomal large subunit rRNA binding activity; pseudouridine synthase activity; and tRNA binding activity. Involved in mitochondrial tRNA pseudouridine synthesis and positive regulation of mitochondrial translation. Located in mitochondrion; nucleoplasm; and ribonucleoprotein granule.
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