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The antibody against RSPO2 was raised in rabbit using the Human RSPO2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against RSPO2 was raised in rabbit using the Human RSPO2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-47290A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RSPO2 |
| Target Synonyms | RSPO2 antibody; UNQ9384/PRO34209 antibody; R-spondin-2 antibody; Roof plate-specific spondin-2 antibody; hRspo2 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Human RSPO2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6UXX9 |
Uniprot Id
Q6UXX9
Target Species
Human
Target Name
RSPO2
Target Full Name
R-spondin-2
Target Function
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form.
Target Subcellular Location
Secreted.
Target Protein Families
R-spondin family
Target Synonyms
RSPO2; UNQ9384/PRO34209; R-spondin-2; Roof plate-specific spondin-2; hRspo2
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