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The antibody against RTN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human RTN1 (NP_066959.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against RTN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human RTN1 (NP_066959.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00292A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RTN1 |
| Target Synonyms | NSP; RTN1 | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse lung | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human RTN1 (NP_066959.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q16799 | Immunogen Sequence |
Uniprot Id
Q16799
Target Species
Human
Target Name
RTN1
Target Full Name
Reticulon-1
Target Function
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Target Tissue Specificity
Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation.
Target Synonyms
RTN1; NSP; Reticulon-1; Neuroendocrine-specific protein
Target Background
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants.
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