Rabbit anti-Human RTN4RL1 Polyclonal Antibody

Uniprot Id

Q86UN2

Target Species

Human

Target Name

RTN4RL1

Target Full Name

Reticulon-4 receptor-like 1

Target Function

Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton.

Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Perikaryon. Cell projection.

Target Protein Families

Nogo receptor family

Target Tissue Specificity

Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.

Target Synonyms

DKFZp547J144; NgR 3; NgR3; NGRH 2; NGRH2; NGRL2; Nogo 66 receptor homolog 2; Nogo 66 receptor related protein 3; Nogo receptor like 2; Nogo receptor-like 2; Nogo-66 receptor homolog 2; Nogo-66 receptor-related protein 3; R4RL1_HUMAN; Reticulon 4 receptor like 1; Reticulon-4 receptor-like 1; RTN4RL1

Target Background

Enables signaling receptor activity. Predicted to be involved in negative regulation of axon regeneration. Located in cell surface. Is anchored component of plasma membrane.