Rabbit anti-Human S100/S100A1 Polyclonal Antibody

Uniprot Id

P23297

Target Species

Human

Target Name

S100A1

Target Full Name

Protein S100-A1

Target Function

Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole.

Target Subcellular Location

Cytoplasm. Sarcoplasmic reticulum. Mitochondrion.

Target Protein Families

S-100 family

Target Tissue Specificity

Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.

Target Research Area

Signal Transduction

Target Synonyms

Bpb; NEF; Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 alpha; S100 beta; S100 calcium binding protein A1; S100 calcium binding protein B; S100 calcium-binding protein A1; S100 protein alpha polypeptide; S100A; s100a1; S100B; S100beta; S10A1_HUMAN

Target Background

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.