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The antibody against SARS was raised in rabbit using the Recombinant Human Serine--tRNA ligase, cytoplasmic protein (2-233AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against SARS was raised in rabbit using the Recombinant Human Serine–tRNA ligase, cytoplasmic protein (2-233AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human placenta tissue using SARS Antibody at dilution of 1:1002
| Cat.No | ADC-50425A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SARS |
| Target Synonyms | C78314 antibody; cytoplasmic antibody; EC 6.1.1.11 antibody; FLJ36399 antibody; sarS antibody; Sars1 antibody; Serine tRNA ligase 1, cytoplasmic antibody; Serine tRNA ligase antibody; Serine--tRNA ligase antibody; serine--tRNA ligase, cytoplasmic antibody; Seryl-tRNA(Ser/Sec) synthetase antibody; Strs antibody; SYSC_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Serine--tRNA ligase, cytoplasmic protein (2-233AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P49591 |
Uniprot Id
P49591
Target Species
Human
Target Name
SARS
Target Full Name
Serine--tRNA ligase, cytoplasmic
Target Function
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Class-II aminoacyl-tRNA synthetase family, Type-1 seryl-tRNA synthetase subfamily
Target Tissue Specificity
Brain.
Target Research Area
Metabolism
Target Synonyms
C78314; cytoplasmic; EC 6.1.1.11; FLJ36399; sarS; Sars1; Serine tRNA ligase 1, cytoplasmic; Serine tRNA ligase; Serine--tRNA ligase; serine--tRNA ligase, cytoplasmic; SerRS; SERS; Seryl tRNA Ser/Sec synthetase; Seryl tRNA synthetase; Seryl tRNA synthetase cytoplasmic; Seryl-tRNA Ser/Sec synthetase; Seryl-tRNA synthetase; seryl-tRNA synthetase, cytoplasmic; Seryl-tRNA(Ser/Sec) synthetase; Strs; SYSC_HUMAN
Target Background
This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown.
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