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The antibody against SBNO2 was raised in rabbit using the Recombinant Human Protein strawberry notch homolog 2 protein (6-146AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against SBNO2 was raised in rabbit using the Recombinant Human Protein strawberry notch homolog 2 protein (6-146AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
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Immunofluorescent analysis of HepG2 cells using SBNO2 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-14125A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SBNO2 |
| Target Synonyms | SBNO2 antibody; KIAA0963Protein strawberry notch homolog 2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein strawberry notch homolog 2 protein (6-146AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y2G9 |
Uniprot Id
Q9Y2G9
Target Species
Human
Target Name
SBNO2
Target Full Name
Protein strawberry notch homolog 2
Target Function
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the proinflammatory cascade.
Target Protein Families
SBNO family
Target Tissue Specificity
Detected in macrophages. IL10 regulates expression in a STAT3-dependent way.
Target Synonyms
SBNO2; KIAA0963Protein strawberry notch homolog 2
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