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The antibody against SCAF4 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human SFRS15. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against SCAF4 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human SFRS15. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
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Western Blot analysis of COLO cells using SFRS15 Polyclonal Antibody
| Cat.No | ADC-34401A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SCAF4 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human SFRS15. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95104 |
Uniprot Id
O95104
Target Species
Human
Target Name
SCAF4
Target Full Name
SR-related and CTD-associated factor 4
Target Function
Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough.
Target Subcellular Location
Nucleus.
Target Protein Families
Splicing factor SR family
Target Synonyms
SCAF4; KIAA1172; SFRS15; SR-related and CTD-associated factor 4; CTD-binding SR-like protein RA4; Splicing factor; arginine/serine-rich 15
Target Background
This gene likely encodes a member of the arginine/serine-rich splicing factor family. A similar protein in Rat appears to bind the large subunit of RNA polymerase II and provide a link between transcription and pre-mRNA splicing. Alternatively spliced transcript variants have been described.
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