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The antibody against SCN10A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1727-1956 of human SCN10A (NP_006505.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
The antibody against SCN10A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1727-1956 of human SCN10A (NP_006505.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
Immunofluorescence analysis of Neuro-2a cells using SCN10A Rabbit pAb at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.
| Cat.No | ADA-03347A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SCN10A |
| Target Synonyms | PN3; SNS; FEPS2; Nav1.8; SCN10A | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1727-1956 of human SCN10A (NP_006505.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y5Y9 | Immunogen Sequence |
Uniprot Id
Q9Y5Y9
Target Species
Human
Target Name
SCN10A
Target Full Name
Sodium channel protein type 10 subunit alpha
Target Function
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
Target Involvement
Episodic pain syndrome, familial, 2 (FEPS2)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
Sodium channel (TC 1.A.1.10) family, Nav1.8/SCN10A subfamily
Target Tissue Specificity
Expressed in the dorsal root ganglia and sciatic nerve.
Target Synonyms
PN3; SNS; FEPS2; Nav1.8; SCN10A
Target Background
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants.
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