Rabbit anti-Human SCN3A Polyclonal Antibody

Uniprot Id

Q9NY46

Target Species

Human

Target Name

SCN3A

Target Full Name

Sodium channel protein type 3 subunit alpha

Target Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells. In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Sodium channel (TC 1.A.1.10) family, Nav1.3/SCN3A subfamily

Target Tissue Specificity

Expressed in enterochromaffin cells in both colon and small bowel (at protein level).

Target Synonyms

brain III voltage-gated sodium channel; NAC3; Nav1.3; SCN3A; SCN3A_HUMAN; Sodium channel protein brain III subunit alpha; Sodium channel protein type 3 subunit alpha; Sodium channel protein type III subunit alpha; Sodium channel protein, brain III subunit alpha; sodium channel, brain type III, alpha subunit; sodium channel, neuronal type III, alpha subunit; sodium channel, voltage-gated, type III, alpha polypeptide; sodium channel, voltage-gated, type III, alpha subunit; Voltage gated sodium channel subtype III; Voltage gated sodium channel subunit alpha Nav1.3; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.3

Target Background

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.