Rabbit anti-Human SCNN1G Polyclonal Antibody

Uniprot Id

P51170

Target Species

Human

Target Name

SCNN1G

Target Full Name

Epithelial sodium channel subunit gamma

Target Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

Target Involvement

Liddle syndrome (LIDLS); Bronchiectasis with or without elevated sweat chloride 3 (BESC3)

Target Subcellular Location

Apical cell membrane; Multi-pass membrane protein.

Target Protein Families

Amiloride-sensitive sodium channel (TC 1.A.6) family, SCNN1G subfamily

Target Tissue Specificity

Expressed in kidney (at protein level).

Target Synonyms

Amiloride sensitive epithelial sodium channel gamma subunit; Amiloride sensitive sodium channel subunit gamma; Amiloride-sensitive sodium channel subunit gamma; BESC3; ENaC gamma subunit; ENaCG; ENaCgamma; Epithelial Na(+) channel subunit gamma; Epithelial Na+ channel subunit gamma; Gamma ENaC; Gamma NaCH; Gamma-ENaC; Gamma-NaCH; Nonvoltage gated sodium channel 1 subunit gamma; Nonvoltage-gated sodium channel 1 subunit gamma; PHA 1; PHA1; SCNEG; SCNN 1G; SCNN1G; SCNNG_HUMAN; Sodium channel epithelial 1 gamma subunit; Sodium channel non voltage gated 1 gamma subunit; Sodium channel nonvoltage gated 1 gamma

Target Background

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome.