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Rabbit anti-Human SDHA Polyclonal Antibody, HRP conjugated

The antibody against SDHA was raised in rabbit using the Recombinant Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial protein (44-293AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

ADC-54470A

The antibody against SDHA was raised in rabbit using the Recombinant Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial protein (44-293AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

$299.00

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Specifications


Cat.No ADC-54470A ClonalityPolyclonal
Host SpeciesRabbitTarget NameSDHA
FormLiquidSpecies ReactivityHuman
IsotypeIgGStorage Buffer0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4
Purification Method>95%, Protein G purifiedConjugateHRP conjugated
ApplicationELISAStorageUpon receipt

Immunogen Information


Immunogen DescriptionRecombinant Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial protein (44-293AA)Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDP31040
Background Information
  • Uniprot Id

    P31040

  • Target Species

    Human

  • Target Name

    SDHA

  • Target Full Name

    Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

  • Target Function

    Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.

  • Target Involvement

    Mitochondrial complex II deficiency (MT-C2D); Leigh syndrome (LS); Cardiomyopathy, dilated 1GG (CMD1GG); Paragangliomas 5 (PGL5)

  • Target Subcellular Location

    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

  • Target Protein Families

    FAD-dependent oxidoreductase 2 family, FRD/SDH subfamily

  • Target Research Area

    Transport

  • Target Synonyms

    CMD1GG; DHSA_HUMAN; Flavoprotein subunit of complex II; Fp; PGL5; SDH 2; SDH1; SDH2; SDHA; SDHF; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Succinate dehydrogenase [ubiquinone] flavoprotein subunit mitochondrial; Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Succinate dehydrogenase complex flavoprotein subunit A; Succinate dehydrogenase complex flavoprotein subunit; Succinate dehydrogenase complex flavoprotein subunit precursor; Succinate dehydrogenase complex subunit A; Succinate dehydrogenase complex subunit A flavoprotein (Fp); Succinate dehydrogenase complex subunit A flavoprotein

  • Target Background

    This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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