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The antibody against SEC14L2 was raised in Rabbit using the recombinant Protein corresponding to a sequence within amino acids 1-275 of human SEC14L2(NP_203740.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
The antibody against SEC14L2 was raised in Rabbit using the recombinant Protein corresponding to a sequence within amino acids 1-275 of human SEC14L2(NP_203740.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
Immunohistochemistry analysis of?SEC14L2 in paraffin-embedded?rat liver tissue using?SEC14L2 Rabbit pAb at a dilution of 1:100 (40x lens).?High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.
| Cat.No | ADA-08262A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SEC14L2 |
| Target Synonyms | SEC14L2; C22orf6; SPF; TAP; TAP1; SEC14-like protein 2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IHC-P |
| Immunogen Description | Recombinant Protein corresponding to a sequence within amino acids 1-275 of human SEC14L2(NP_203740.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O76054 | Immunogen Sequence |
Uniprot Id
O76054
Target Species
Human
Target Name
SEC14L2
Target Full Name
SEC14-like protein 2
Target Function
Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
Target Subcellular Location
Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.
Target Tissue Specificity
Widely expressed. Strong expression in liver, brain and prostate.
Target Synonyms
Alpha tocopherol associated protein; Alpha-tocopherol-associated protein; C22orf6 ; hTAP; KIAA1186 ; KIAA1658 ; MGC65053 ; OTTHUMP00000198972; OTTHUMP00000198973; OTTHUMP00000198974; OTTHUMP00000199021; S14L2_HUMAN; SEC14 (S. cerevisiae) like 2; SEC14 like 2 (S. cerevisiae) ; SEC14 like protein 2; SEC14-like protein 2; Sec14l2; SPF; Squalene transfer protein; Supernatant protein factor; TAP; TAP1 ; tocopherol-associated protein
Target Background
This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
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