Rabbit anti-Human SEC24C Polyclonal Antibody

Uniprot Id

P53992

Target Species

Human

Target Name

SEC24C

Target Full Name

Protein transport protein Sec24C

Target Function

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B. May more specifically package GPI-anchored proteins through the cargo receptor TMED10. May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5.

Target Subcellular Location

Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.

Target Protein Families

SEC23/SEC24 family, SEC24 subfamily

Target Tissue Specificity

Ubiquitous.

Target Synonyms

Protein transport protein Sec24C; SC 24C; SC24 C; SC24C; SC24C_HUMAN; Sec 24C; Sec24 C; SEC24 related gene family, member C (S. cerevisiae); SEC24 related protein C; SEC24-related protein C; SEC24C

Target Background

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified.