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The antibody against SEPT11 was raised in rabbit using the Recombinant Human Septin-11 protein (237-429AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, antigen affinity purified & affinity purified with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against SEPT11 was raised in rabbit using the Recombinant Human Septin-11 protein (237-429AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, antigen affinity purified & affinity purified with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
Western Blot | Positive WB detected in: SH-SY5Y whole cell lysate, Rat brain tissue, Rat liver tissue | All lanes: SEPT11 antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 50, 51 kDa | Observed band size: 50 kDa
| Cat.No | ADC-00645A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SEPT11 |
| Target Synonyms | SEP11_HUMAN antibody; SEPT 11 antibody; Sept11 antibody; Septin-11 antibody; Septin11 antibody | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Antigen Affinity purified & Affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Septin-11 protein (237-429AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NVA2 |
Uniprot Id
Q9NVA2
Target Species
Human
Target Name
SEPT11
Target Full Name
Septin-11
Target Function
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity. During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.
Target Involvement
A chromosomal aberration involving SEPT11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with KMT2A/MLL1.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell junction, synapse. Cell projection, dendritic spine. Cell projection, axon. Note=Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
Target Protein Families
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
Target Tissue Specificity
Widely expressed, except in leukocytes.
Target Synonyms
SEP11_HUMAN; SEPT 11; Sept11; Septin-11; Septin11
Target Background
SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).
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