Rabbit anti-Human Septin 11 Polyclonal Antibody

The antibody against Septin 11 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human Septin 11 (NP_060713.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-02229A

Number

Cat.No	ADA-02229A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	Septin 11
Target Synonyms	SEPT11; Septin 11	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, NIH/3T3, Rat brain, 293T, Mouse brain, Rat spleen	Application	ELISA, WB

Cat.No

ADA-02229A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

Septin 11

Target Synonyms

SEPT11; Septin 11

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, NIH/3T3, Rat brain, 293T, Mouse brain, Rat spleen

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human Septin 11 (NP_060713.1).	Target Species	Human
Immunogen Sequence	MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEY	Uniprot ID	Q9NVA2

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human Septin 11 (NP_060713.1).

Target Species

Human

Immunogen Sequence

MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEY

Uniprot ID

Q9NVA2

Background Information

Uniprot Id

Q9NVA2
Target Species

Human
Target Name

SEPT11
Target Full Name

Septin-11
Target Function

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity. During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.
Target Involvement

A chromosomal aberration involving SEPT11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with KMT2A/MLL1.
Target Subcellular Location

Cytoplasm, cytoskeleton. Cell junction, synapse. Cell projection, dendritic spine. Cell projection, axon. Note=Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
Target Protein Families

TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
Target Tissue Specificity

Widely expressed, except in leukocytes.
Target Synonyms

SEP11_HUMAN; SEPT 11; Sept11; Septin-11; Septin11
Target Background

SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).

Rabbit anti-Human Septin 11 Polyclonal Antibody

Specifications

Immunogen Information

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