Rabbit anti-Human SERPINB1 Polyclonal Antibody

Uniprot Id

P30740

Target Species

Human

Target Name

SERPINB1

Target Full Name

Leukocyte elastase inhibitor

Target Function

Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function.

Target Subcellular Location

Secreted. Cytoplasm. Cytolytic granule. Early endosome.

Target Protein Families

Serpin family, Ov-serpin subfamily

Target Tissue Specificity

In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes.

Target Research Area

Cardiovascular

Target Synonyms

Anti elastase ; EI; ELANH2 ; Epididymis luminal protein 57; HEL57; ILEU_HUMAN; LEI; Leukocyte elastase inhibitor; M/NEI; MNEI ; Monocyte/neutrophil elastase inhibitor; Peptidase inhibitor 2; Pi-2; PI2 ; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 1; Serpin B1; Serpin peptidase inhibitor clade B (ovalbumin) member 1; serpinb1

Target Background

The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants.