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The antibody against SESN3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human SESN3 (NP_653266.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against SESN3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human SESN3 (NP_653266.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-11215A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SESN3 |
| Target Synonyms | SEST3; SESN3 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, A-549 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human SESN3 (NP_653266.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P58005 | Immunogen Sequence |
Uniprot Id
P58005
Target Species
Human
Target Name
SESN3
Target Full Name
Sestrin-3
Target Function
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Sestrin family
Target Tissue Specificity
Widely expressed.
Target Research Area
Cancer
Target Synonyms
MGC29667; OTTHUMP00000236979; OTTHUMP00000236986; SESN3; SESN3_HUMAN; SEST3; Sestrin 3; Sestrin-3
Target Background
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.
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