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The antibody against SESN3 was raised in rabbit using the Full length fusion protein as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against SESN3 was raised in rabbit using the Full length fusion protein as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-29290A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SESN3 |
| Target Synonyms | MGC29667 antibody; OTTHUMP00000236979 antibody; OTTHUMP00000236986 antibody; SESN3 antibody; SESN3_HUMAN antibody; SEST3 antibody; Sestrin 3 antibody; Sestrin-3 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Full length fusion protein | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P58005 |
Uniprot Id
P58005
Target Species
Human
Target Name
SESN3
Target Full Name
Sestrin-3
Target Function
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Sestrin family
Target Tissue Specificity
Widely expressed.
Target Research Area
Cancer
Target Synonyms
MGC29667; OTTHUMP00000236979; OTTHUMP00000236986; SESN3; SESN3_HUMAN; SEST3; Sestrin 3; Sestrin-3
Target Background
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.
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