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The antibody against SH3GL2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SH3GL2 (NP_003017.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against SH3GL2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SH3GL2 (NP_003017.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09657A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SH3GL2 |
| Target Synonyms | CNSA2; SH3P4; EEN-B1; SH3D2A; SH3GL2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T, BT-474, HepG2, Mouse brain, Mouse testis | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SH3GL2 (NP_003017.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q99962 | Immunogen Sequence |
Uniprot Id
Q99962
Target Species
Human
Target Name
SH3GL2
Target Full Name
Endophilin-A1
Target Function
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Target Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Cell junction, synapse, presynapse.
Target Protein Families
Endophilin family
Target Tissue Specificity
Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
Target Synonyms
bA335L15.1 (SH3 domain GRB2 like 2); CNSA2; EEN B1; EEN-B1; Endophilin 1; Endophilin A1; Endophilin A1 BAR domain; Endophilin-1; Endophilin-A1; FLJ20276; FLJ25015; OTTHUMP00000021084; SH3 domain containing GRB2 like protein 2; SH3 domain GRB2 like 2; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3D2A; SH3G2_HUMAN; Sh3gl2; Sh3p4; SH3PA
Target Background
Enables identical protein binding activity. Involved in negative regulation of blood-brain barrier permeability; negative regulation of gene expression; and negative regulation of protein phosphorylation. Located in perinuclear region of cytoplasm.
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