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The antibody against SH3PXD2A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 806-1105 of human SH3PXD2A (NP_055446.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against SH3PXD2A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 806-1105 of human SH3PXD2A (NP_055446.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-10873A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SH3PXD2A |
| Target Synonyms | FISH; TKS5; SH3MD1; SH3PXD2A | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 806-1105 of human SH3PXD2A (NP_055446.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q5TCZ1 | Immunogen Sequence |
Uniprot Id
Q5TCZ1
Target Species
Human
Target Name
SH3PXD2A
Target Full Name
SH3 and PX domain-containing protein 2A
Target Function
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
Target Subcellular Location
Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
Target Protein Families
SH3PXD2 family
Target Tissue Specificity
Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.
Target Research Area
Others
Target Synonyms
Adapter protein TKS5; Five SH3 domain-containing protein; SH3 and PX domain-containing protein 2A; SH3 multiple domains protein 1; Sh3md1; Sh3pxd2a; SPD2A_HUMAN; TKs5; Tyrosine kinase substrate with five SH3 domains
Target Background
Predicted to enable superoxide-generating NADPH oxidase activator activity. Involved in osteoclast fusion and superoxide metabolic process. Located in podosome.
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