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The antibody against SHOC2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human SHOC2 (NP_031399.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against SHOC2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human SHOC2 (NP_031399.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-03996A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SHOC2 |
| Target Synonyms | SOC2; SUR8; NSLH1; SIAA0862; SHOC2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Jurkat, MCF7, Mouse brain, Mouse lung, Mouse spleen, Rat testis, U-87MG | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human SHOC2 (NP_031399.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9UQ13 | Immunogen Sequence |
Uniprot Id
Q9UQ13
Target Species
Human
Target Name
SHOC2
Target Full Name
Leucine-rich repeat protein SHOC-2
Target Function
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Target Involvement
Noonan syndrome-like disorder with loose anagen hair 1 (NSLH1)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
SHOC2 family
Target Synonyms
KIAA0862; Leucine-rich repeat protein SHOC-2; Protein soc-2 homolog; Protein Sur-8 homolog; Ras-binding protein Sur-8; SHOC2; SHOC2_HUMAN
Target Background
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair.
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