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The antibody against SHPK was raised in rabbit using the Synthesized peptide derived from N-terminal of Human CARKL. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
The antibody against SHPK was raised in rabbit using the Synthesized peptide derived from N-terminal of Human CARKL. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
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Western blot analysis of extracts from Jurkat cells, using CARKL antibody.
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using CARKL antibody.2
| Cat.No | ADC-41766A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SHPK |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from N-terminal of Human CARKL. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UHJ6 |
Uniprot Id
Q9UHJ6
Target Species
Human
Target Name
SHPK
Target Full Name
Sedoheptulokinase
Target Function
Acts as a modulator of macrophage activation through control of glucose metabolism.
Target Involvement
Sedoheptulokinase deficiency (SHPKD)
Target Subcellular Location
Cytoplasm.
Target Protein Families
FGGY kinase family
Target Tissue Specificity
Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain.
Target Synonyms
Carbohydrate kinase like; Carbohydrate kinase like protein ; Carbohydrate kinase-like protein; CARKL; Sedoheptulokinase; SHK; Shpk; SHPK_HUMAN
Target Background
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements.
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