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The antibody against SIK3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-310 of human SIK3 (NP_079440.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against SIK3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-310 of human SIK3 (NP_079440.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06728A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SIK3 |
| Target Synonyms | L19; QSK; SEMDK; SIK-3; SIK3 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293F | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 60-310 of human SIK3 (NP_079440.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y2K2 | Immunogen Sequence |
Uniprot Id
Q9Y2K2
Target Species
Human
Target Name
SIK3
Target Full Name
Serine/threonine-protein kinase SIK3
Target Function
Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3. Prevents HDAC4 translocation to the nucleus.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Target Tissue Specificity
Expressed in chondrocytes.
Target Synonyms
SIK3; KIAA0999; QSK; L19Serine/threonine-protein kinase SIK3; EC 2.7.11.1; Salt-inducible kinase 3; SIK-3; Serine/threonine-protein kinase QSK
Target Background
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; and protein phosphorylation. Located in nucleoplasm.
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