Rabbit anti-Human SLC27A1 Polyclonal Antibody

Uniprot Id

Q6PCB7

Target Species

Human

Target Name

SLC27A1

Target Full Name

Long-chain fatty acid transport protein 1

Target Function

Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier.

Target Subcellular Location

Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Cytoplasm.

Target Protein Families

ATP-dependent AMP-binding enzyme family

Target Tissue Specificity

Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. Expressed in brain gray matter.

Target Synonyms

SLC27A1; ACSVL5; FATP1Long-chain fatty acid transport protein 1; FATP-1; Fatty acid transport protein 1; EC 6.2.1.-; Solute carrier family 27 member 1

Target Background

Enables biotin transmembrane transporter activity; efflux transmembrane transporter activity; and long-chain fatty acid transporter activity. Involved in several processes, including carboxylic acid transmembrane transport; glycerophospholipid biosynthetic process; and lipid transport across blood-brain barrier. Located in membrane. Part of plasma membrane.