Rabbit anti-Human SLC34A3 Polyclonal Antibody

Uniprot Id

Q8N130

Target Species

Human

Target Name

SLC34A3

Target Full Name

Sodium-dependent phosphate transport protein 2C

Target Function

May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.

Target Involvement

Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

SLC34A transporter family

Target Synonyms

HHRH ; Na(+) dependent phosphate cotransporter 2C ; Na(+) Pi cotransporter 2C; Na(+)-dependent phosphate cotransporter 2C; Na(+)/Pi cotransporter 2C; NaPi 2c; NaPi-2c; NPT2C ; NPT2C_HUMAN; NPTIIC ; SLC34A3; Sodium dependent phosphate transport protein 2C; Sodium inorganic phosphate cotransporter IIC; Sodium phosphate cotransporter 2C; Sodium phosphate transport protein 2C ; Sodium-dependent phosphate transport protein 2C; Sodium-phosphate transport protein 2C; Sodium/inorganic phosphate cotransporter IIC; Sodium/inorganic phosphate cotransporter; type IIC; Sodium/phosphate cotransporter 2C; solute carrier family 34 (sodium phosphate) member 3; solute carrier family 34 (sodium/phosphate contransporter); member 3; solute carrier family 34 (type II sodium/phosphate contransporter); member 3; Solute carrier family 34 member 3; type IIc Na+ Pi cotransporter ; Type IIc Na+/Pi cotransporter

Target Background

This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.